Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf8  fibroblast growth factor 8   (Synonyms: Aigf, Fgf-8)
Results	Reference
1	J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50
1*	J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
1	J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81
1	J:114854 Aggarwal VS, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, Shanske A, Campione M, Morrow BE, Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet. 2006 Nov 1;15(21):3219-28
1*	J:71880 Beverdam A, Brouwer A, Reijnen M, Korving J, Meijlink F, Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development. 2001 Oct;128(20):3975-86
1*	J:108509 Blaess S, Corrales JD, Joyner AL, Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development. 2006 May;133(9):1799-809
1	J:137136 Blaess S, Stephen D, Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
1	J:98791 Blak AA, Naserke T, Weisenhorn DM, Prakash N, Partanen J, Wurst W, Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Dev Dyn. 2005 Apr 13;233(3):1023-1030
1	J:160580 Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL, FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008;3:17
1	J:190545 Boulet AM, Capecchi MR, Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
1	J:299537 Boylan M, Anderson MJ, Ornitz DM, Lewandoski M, The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. Development. 2020 Oct 19;147(21):dev189506
1	J:36587 Bueno D, Skinner J, Abud H, Heath JK, Spatial and temporal relationships between Shh, Fgf4, and Fgf8 gene expression at diverse signalling centers during mouse development. Dev Dyn. 1996 Nov;207(3):291-9
1	J:100584 Byrd NA, Meyers EN, Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005 Aug 1;284(1):233-45
1	J:161813 Chilov D, Sinjushina N, Saarimaki-Vire J, Taketo MM, Partanen J, beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One. 2010;5(6):e10881
1*	J:23136 Crossley PH, Martin GR, The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development. 1995 Feb;121(2):439-51
1	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1	J:88261 Dubrulle J, Pourquie O, fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature. 2004 Jan 29;427(6973):419-22
1*	J:207523 Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13
1*	J:46975 Ericson J, Norlin S, Jessell TM, Edlund T, Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development. 1998 Mar;125(6):1005-15
1	J:170384 Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N, Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Dev Biol. 2011 Feb 15;350(2):496-510
1	J:229902 Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP, Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57
1	J:108511 Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development. 2006 May;133(9):1779-87
1	J:172023 Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X, A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
1	J:96705 Hamasaki T, Leingartner A, Ringstedt T, O'Leary DD, EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors. Neuron. 2004 Aug 5;43(3):359-72
1	J:228784 Haro E, Delgado I, Junco M, Yamada Y, Mansouri A, Oberg KC, Ros MA, Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development. PLoS Genet. 2014 Aug;10(8):e1004468
1*	J:21239 Heikinheimo M, Lawshe A, Shackleford GM, Wilson DB, MacArthur CA, Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 1994 Nov;48(2):129-38
1	J:152574 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA, Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96
1	J:93588 Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D, Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502
1	J:109474 Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN, Fgf8 is required for anterior heart field development. Development. 2006 Jun;133(12):2435-45
1*	J:213586 Jackson A, Kasah S, Mansour SL, Morrow B, Basson MA, Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. Dev Dyn. 2014 Sep;243(9):1143-51
1	J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
1	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
1	J:66020 LaMantia A, Bhasin N, Rhodes K, Heemskerk J, Mesenchymal/Epithelial induction mediates olfactory pathway formation. Neuron. 2000 Nov;28(2):411-25
1	J:79431 Li JY, Lao Z, Joyner AL, Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron. 2002 Sep 26;36(1):31-43
1*	J:58078 Liu A, Losos K, Joyner AL, FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development. 1999 Nov;126(21):4827-38
1	J:87220 Liu W, Selever J, Lu MF, Martin JF, Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development. 2003 Dec;130(25):6375-85
1	J:106308 Liu Y, Festing M, Thompson JC, Hester M, Rankin S, El-Hodiri HM, Zorn AM, Weinstein M, Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev Biol. 2004 Jun 15;270(2):411-26
1	J:343069 Lodge EJ, Barrell WB, Liu KJ, Andoniadou CL, The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development. J Anat. 2023 Oct 4;
1*	J:28252 Mahmood R, Bresnick J, Hornbruch A, Mahony C, Morton N, Colquhoun K, Martin P, Lumsden A, Dickson C, Mason I, A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol. 1995 Jul 1;5(7):797-806
1	J:181153 Mesbah K, Rana MS, Francou A, van Duijvenboden K, Papaioannou VE, Moorman AF, Kelly RG, Christoffels VM, Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet. 2012 Mar 15;21(6):1217-29
1	J:91163 Mic FA, Sirbu IO, Duester G, Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. J Biol Chem. 2004 Jun 18;279(25):26698-706
1	J:50768 Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS, Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 1998 Oct 15;12(20):3156-61
1	J:206578 Nonomura K, Yamaguchi Y, Hamachi M, Koike M, Uchiyama Y, Nakazato K, Mochizuki A, Sakaue-Sawano A, Miyawaki A, Yoshida H, Kuida K, Miura M, Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells. Dev Cell. 2013 Dec 23;27(6):621-34
1*	J:21078 Ohuchi H, Yoshioka H, Tanaka A, Kawakami Y, Nohno T, Noji S, Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem Biophys Res Commun. 1994 Oct 28;204(2):882-8
1	J:179736 Paek H, Antoine MW, Diaz F, Hebert JM, Increased beta-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev Dyn. 2012 Feb;241(2):242-6
1	J:188279 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N, A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation. J Neurosci. 2012 Sep 19;32(38):13292-13308
1	J:282947 Poncet N, Halley PA, Lipina C, Gierlinski M, Dady A, Singer GA, Febrer M, Shi YB, Yamaguchi TP, Taylor PM, Storey KG, Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. EMBO Rep. 2020 Jan 7;21(1):e48469
1*	J:149241 Qiu Q, Chen H, Johnson RL, Lmx1b-expressing cells in the mouse limb bud define a dorsal mesenchymal lineage compartment. Genesis. 2009 Apr;47(4):224-33
1	J:128002 Rizzoti K, Lovell-Badge R, SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007 Oct;134(19):3437-48
1	J:129204 Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, Paterson C, Lejsek E, Arnold SJ, Kallies A, Nutt SL, Bikoff EK, Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development. 2007 Dec;134(24):4335-45
1	J:114449 Robledo RF, Lufkin T, Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Genesis. 2006 Sep;44(9):425-37
1*	J:226322 Roux M, Laforest B, Capecchi M, Bertrand N, Zaffran S, Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. Dev Biol. 2015 Oct 15;406(2):247-58
1	J:243695 Sherf O, Nashelsky Zolotov L, Liser K, Tilleman H, Jovanovic VM, Zega K, Jukic MM, Brodski C, Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. PLoS One. 2015;10(10):e0139697
1	J:270109 Sugrue KF, Sarkar AA, Leatherbury L, Zohn IE, The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch. Dis Model Mech. 2019 Jan 11;12(1):dmm036491
1	J:160732 Thomson RE, Kind PC, Graham NA, Etherson ML, Kennedy J, Fernandes AC, Marques CS, Hevner RF, Iwata T, Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Dev. 2009;4:4
1	J:171333 Tilleman H, Hakim V, Novikov O, Liser K, Nashelsky L, Di Salvio M, Krauthammer M, Scheffner O, Maor I, Mayseless O, Meir I, Kayam G, Sela-Donenfeld D, Simeone A, Brodski C, Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons. Mol Cell Neurosci. 2010 Sep;45(1):1-11
1	J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
1	J:104600 Trokovic R, Jukkola T, Saarimaki J, Peltopuro P, Naserke T, Weisenhorn DM, Trokovic N, Wurst W, Partanen J, Fgfr1-dependent boundary cells between developing mid- and hindbrain. Dev Biol. 2005 Feb 15;278(2):428-39
1	J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1*	J:160266 van Bueren KL, Papangeli I, Rochais F, Pearce K, Roberts C, Calmont A, Szumska D, Kelly RG, Bhattacharya S, Scambler PJ, Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome. Dev Biol. 2010 Apr 15;340(2):369-80
1	J:166929 Wang Y, Martin JF, Bai CB, Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 2010 Dec 15;348(2):199-209
1	J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1*	J:56088 Xu J, Lawshe A, MacArthur CA, Ornitz DM, Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev. 1999 May;83(1-2):165-78
1	J:61429 Xu J, Liu Z, Ornitz DM, Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000 May;127(9):1833-43
1	J:106091 Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D, Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar;59(3):349-54
1*	J:330234 Zbasnik N, Dolan K, Buczkowski SA, Green RM, Hallgrimsson B, Marcucio RS, Moon AM, Fish JL, Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships. Dev Dyn. 2022 Oct;251(10):1711-1727
1	J:112457 Zhang Z, Huynh T, Baldini A, Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006 Sep;133(18):3587-95